Convergent microRNA actions coordinate neocortical development
نویسندگان
چکیده
منابع مشابه
Neocortical Development
The material contained in this volume was submitted as previously unpublished material, except in the instances in which credit has been given to the source from which some of the illustrative material was derived. Great care has been taken to maintain the accuracy of the information contained in the volume. However, neither Raven Press nor the authors can be held responsible for errors or for ...
متن کاملMicroRNA-independent functions of DGCR8 are essential for neocortical development and TBR1 expression.
Recent evidence indicates that the miRNA biogenesis factors DROSHA, DGCR8, and DICER exert non-overlapping functions, and have also roles in miRNA-independent regulatory mechanisms. However, it is currently unknown whether miRNA-independent functions of DGCR8 play any role in the maintenance of neuronal progenitors and during corticogenesis. Here, by phenotypic comparison of cortices from condi...
متن کاملProvably convergent coordinate descent in statistical tomographic reconstruction
Statistical tomographic reconstruction algorithms generally require the efficient optimization of a functional. A recent algorithm known as iterative coordinate descent with Newton-Raphson updates (ICD/NR) has been shown to be much more computationally efficient than indirect optimization approaches based on the EM algorithm. However, while the ICD/NR algorithm has experimentally been shown to ...
متن کاملCalcium signaling in neocortical development.
The calcium ion (Ca(2+) ) is an essential second messenger that plays a pivotal role in neurogenesis. In the ventricular zone (VZ) of the neocortex, neural stem cells linger to produce progenitor cells and subsequently neurons and glial cells, which together build up the entire adult brain. The radial glial cells, with their characteristic radial fibers that stretch from the inner ventricular w...
متن کاملSpecialized inhibitory synaptic actions between nearby neocortical pyramidal neurons.
We found that, in the mouse visual cortex, action potentials generated in a single layer-2/3 pyramidal (excitatory) neuron can reliably evoke large, constant-latency inhibitory postsynaptic currents in other nearby pyramidal cells. This effect is mediated by axo-axonic ionotropic glutamate receptor-mediated excitation of the nerve terminals of inhibitory interneurons, which connect to the targe...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cellular and Molecular Life Sciences
سال: 2014
ISSN: 1420-682X,1420-9071
DOI: 10.1007/s00018-014-1576-5